Major Employers in the Texarkana Regional Area
| Business | Number of Employees | Industry |
|---|---|---|
| Christus St. Michael Health System | 2200 | Hospital/Healthcare |
| Red River Army Depot | 2103 | Manufacturer |
| Cooper Tire & Rubber Company | 1820 | Manufacturer |
| Texarkana Texas ISD | 1350 | Education |
| Graphic Packaging | 814 | Manufacturer (Paper) |
| Wal-Mart/Sam's | 802 | Grocery/Retail |
| Wadley Regional Medical Center | 622 | Hospital/Healthcare |
| Ledwell | 611 | Manufacturer |
| Texarkana Arkansas ISD | 603 | Education |
| Domtar | 572 | Manufacturer (Paper) |
| Defense Logistics Agency | 538 | Distribution/Defense |
| City of Texarkana,Texas | 531 | Local Government |
| Texarkana Alumuninum | 420 | Manufacturer |
| Mayo Manufacturing | 220 | Manufacturer |